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Nucleic Acids Symposium Series 2004 48(1):73-74; doi:10.1093/nass/48.1.73
© 2004 by Oxford University Press
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Fluorescent probe for the detection of DNA conformational transition

Yuji Ochi1,3, Akimitsu Okamoto1,3 and Isao Saito2,3

1 Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615-8510, Japan, 2 Faculty of Engineering, NEW CAT Institute, Nihon University, Koriyama 963-8642, Japan, 3 SORST, Japan Science and Technology Corporation

Two pyrene-labeled bases, pyC and 8pyG, have been synthesized and incorporated into d(CG)n. In the CD spectra, structural transition of a modified oligodeoxynucleotide (ODN-Py) from B-form to Z-form has been observed under different salt concentrations. The conformational transition of ODN-Py was monitored by the change of emission wavelengths based on exciplex and monomer fluorescence of pyC and 8pyG.


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