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Nucleic Acids Symposium Series 2004 48(1):79-80; doi:10.1093/nass/48.1.79
© 2004 by Oxford University Press
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Drug release from functionalized oligodeoxynucleotide by photo-induced electron transfer

Yukihiro Tachi, Arimichi Okazaki, Kazuhito Tanabe, Hiroshi Hatta and Sei-ichi Nishimoto

1 Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan

We synthesized a photoreactive hairpin-type oligodeoxynucleotide (P-ODN) possessing an o-nitrobenzyl chromophore and a triplet quencher of 1-aminonaphthalene. Photoirradiation of the hybrid of H-ODN with its complementary DNA led to release of drug in an efficient amount, while the photo-induced drug release was remarkably suppressed in the absence of complementary DNA.


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