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Nucleic Acids Symposium Series 2005 49(1):1-2; doi:10.1093/nass/49.1.1
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© 2005 Oxford University Press

Discrimination of the length of two remote binding sites by the spacer-linked DNA minor groove binders

Mikimasa Tanada1 and Shigeki Sasaki1,2

1 Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, 2 CREST (JST)

The aim of this study is to develop new recognition molecules for the DNA higher-ordered structure on the basis of new concept of DNA recognition mode. In order to bind two remote binding sites of DNA at the same time, we designed the new bidentate ligands that have two Hoechst 33258 units connected by a spacer. DNA binding affinity of the ligands was evaluated by measuring SPR (surface plasmon resonance). As a result, we have achieved discrimination of the length of two remote binding region of a DNA duplex.


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