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Nucleic Acids Symposium Series 2005 49(1):117-118; doi:10.1093/nass/49.1.117
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© 2005 Oxford University Press

Chemical behavior of bis(3'–5')diguanylic acid in aqueous solutions

Mamoru Hyodo1, Yumi Sato1, Yoshihiro Hayakawa1 and David K. R. Karaolis2

1 Graduate School of Information Science/Human Informatics, and CREST/JST, Nagoya University, Chikusa, Nagoya 464-8601, Japan, 2 Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA

This paper describes unique behavior of bis(3'–5')diguanylic acid (c-di-GMP) under some conditions. Thus, c-di-GMP exists as the monomer in aprotic organic solvents such as DMSO. By contrast, c-di-GMP smoothly aggregates in water and in low-concentration aqueous solutions of some salts, such as sodium chloride and ammonium acetate, to give a mixture of many aggregates. The resulting multiple aggregates converge to the single compound (provably the monomer) in a >154 mM (0.9%) sodium chloride aqueous solution, in a >100 mM ammonium acetate buffer, and in a >100 mM phosphate buffer.


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