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Nucleic Acids Symposium Series 2005 49(1):39-40; doi:10.1093/nass/49.1.39
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© 2005 Oxford University Press

Molecular labeling of the CGG trinucleotide repeat

Tao Peng and Kazuhiko Nakatani

The Institute of Scientific and Industrial Research, Osaka University, Ibaraki 567-0047, Japan

The new molecular ligand naphthyridine carbamate dimer (NC), possessing 2-amino-1,8-naphthyridines and a carbamate linker, specially binds to guanine–guanine (G–G) mismatch in duplex DNA. The results of Tm measurements showed that NC selectively bound to CGG/CGG triad with high {Delta}Tm of 23.1 °C. The exclusive stoichiometry 2:1 of the complex of NC with CGG/CGG triad, obtained by the measurements of cold spray ionization time-of-flight mass spectrometry (CSI-TOF MS), showed that NC bound to CGG/CGG triad strongly with two molecules.


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