Skip Navigation

Nucleic Acids Symposium Series 2005 49(1):61-62; doi:10.1093/nass/49.1.61
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gros, J.
Right arrow Articles by Mergny, J.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gros, J.
Right arrow Articles by Mergny, J.-L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 Oxford University Press

Kinetics and thermodynamics of G-quadruplexes

Julien Gros1, Mateus Webba da Silva2, Anne De Cian1, Samir Amrane1, Frédéric Rosu3, Anne Bourdoncle1, Barbara Saccà1, Patrizia Alberti1, Laurent Lacroix1 and Jean-Louis Mergny1 *

1 Laboratoire de Biophysique, INSERM U565, CNRS UMR5153, Muséum National d'Histoire Naturelle, 43 rue Cuvier, 75005 Paris (France), 2 Department of Medicine, Duke University Medical Center, Durham, North Carolina (USA), 3 Laboratoire de Chimie Physique Biologique, Université de Liège, (Belgium)

The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine. Results were compared with the canonical TG4T and TG5T tetramers: we demonstrate huge differences (up to 105-fold) in the association constants of these quadruplexes depending on primary sequence.


* mergny{at}vnumail.com


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.