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Nucleic Acids Symposium Series 2005 49(1):81-82; doi:10.1093/nass/49.1.81
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© 2005 Oxford University Press

Screening of a glutamic acid-binding aptamer from arginine-modified DNA library

Masayasu Kuwahara1,2, Kazuomi Ohsawa1, Toshiyuki Kasamatsu1, Atsushi Shoji1,2, Hiroaki Sawai1 and Hiroaki Ozaki1

1 Department of Applied Chemistry, Fuclty of Engneering, Gunma University, 1-5-1 Tenjin-chou, Kiryu, Gunma 376-8515, Japan, 2 PRESTO (JST)

A binder that is specific for a target will be applicable to detection of a variety of molecules such as bioactive substances, environmental contaminants and so on. Nucleic acid aptamers obtained by in vitro selection method are interesting and promising binders. To enhance the ability of nucleic acid aptamers, we prepared a combinatorial modified DNA library containing arginyl uracil base by using arginyl dUTP, then attempted screening of glutamic acid-binding aptamers from the library by in vitro selection method.


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