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Nucleic Acids Symposium Series 2005 49(1):85-86; doi:10.1093/nass/49.1.85
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© 2005 Oxford University Press

Selection of RNA-aptamer against human influenza B virus

Subash C.B. Gopinath, Kazunori Kawasaki and Penmetcha K.R. Kumar

Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1 Higashi, Tsukuba City 305-8566 Ibaraki, Japan

Developing specific probes that distinguishes types and subtypes of viruses by a single probe will have a great impact not only in developing specific diagnostic reagents but also in developing tailor-made drugs and dosage requirements depending upon the genotype that cause the infection. We have selected aptamers specific for hemagglutinin protein of human influenza virus B/Johannesburg/05/1999. The selected aptamer, Class A-20, bind specifically to hemagglutinin of B/Johannesburg/05/1999 and able to discriminate it from hemagglutinin of human influenza A virus.


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