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Nucleic Acids Symposium Series 2006 50(1):1-2; doi:10.1093/nass/nrl001
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© 2006 Oxford University Press

2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma

Hiroshi Ohrui1, Satoru Kohgo2, Hiroyuki Hayakawa2, Eiichi Kodama3, Masao Matsuoka3, Tomohiro Nakata4 and Hiroyuki Mitsuya4,5

1 Yokohama College of Pharmacy, Yokohama, Japan, 2 Yamasa Corporation, Chiba, Japan, 3 Institute for Virus Research, Kyoto, Japan, 4 Kumamoto University, School of Medicine, Kumamoto, Japan, 5 National Cancer Institute/National Institute of Health, Bethesda, Maryland, USA

A working hypothesis to solve the critical problems of existing HAART was proposed. The study based on the hypothesis proved the validity of the hypothesis and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine (4'Ed2FA), a nucleoside reverse transcriptase inhibitor (NRTI) with highly potent activity against all HIV-1 strains, very favourable toxic profiles, and stability in plasma.


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