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Nucleic Acids Symposium Series 2006 50(1):11-12; doi:10.1093/nass/nrl006
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© 2006 Oxford University Press

A novel RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group

Yoshinobu Shiba, Hidetoshi Kitagawa, Yutaka Masutomi, Kouichi Ishiyama, Tadaaki Ohgi and Junichi Yano

Discovery Research Laboratories, Nippon Shinyaku Co. Ltd., 3-14-1 Sakura, Tsukuba City, Ibaraki 305-0003, Japan

A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2'-hydroxyl protecting group has been developed. The new method allows the synthesis of oligonucleotides with an efficiency and final purity comparable to that obtained in DNA synthesis.1 In addition, the CEM method has the potential for application to the synthesis of very long RNA oligonucleotides.


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