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Nucleic Acids Symposium Series 2006 50(1):187-188; doi:10.1093/nass/nrl093
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© 2006 Oxford University Press

Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis

Tomohisa Moriguchi, Tomoyuki Ohike and Kazuo Shinozuka

Department of Chemistry, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan

A Novel anthraquinone-trisamine modified DNA conjugate was developed. The trisamine-bearing 2,7-disubstituted anthraquinone derivative was introduced into the central position of the DNA oligomer. The ability of the sequence-specific RNA cleavage of this novel modified DNA was investigated.


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