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Nucleic Acids Symposium Series 2007 51(1):23-24; doi:10.1093/nass/nrm012
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© 2007 Oxford University Press

Design of dual-labeled oligonucleotide probes for SNPs genotyping

Yoshio Saito1,*, Subhendu Sekhar Bag2, Satoshi Kodate1 and Isamu Suzuka1

1Department of Marerials Chemistry and Engineering, School of Engineering, and
2NEWCAT Institute, Graduate school of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan.

*Corresponding Author. saito{at}mech.ce.nihon-u.ac.jp

Abstract

Our effort in designing base-discriminating fluorescence nucleosides (BDF), leads us to develop dual-labeled oligonucleotide probe in which the BDF nucleoside, PyU/2-AntU act as the donor separated by a defined base pair distance from the acceptor, fluorescein, attached to 5'-end of the probe. Thus, a longer wavelength emission from acceptor might allow the probe to be used for SNP typing in chip based detection technology or in cell.


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