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Nucleic Acids Symposium Series 2007 51(1):5-6; doi:10.1093/nass/nrm003
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© 2007 Oxford University Press

Development of novel thioguanosine analogs with the ability to specifically modify cytidine{dagger}1

Kazumitsu Onizuka, Yosuke Taniguchi and Shigeki Sasaki*

Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, CREST (JST)

* sasaki{at}phar.kyushu-u.ac.jp

Abstract

Site-specific modification of nucleic acid is of great significance in the machinery of gene expression. Specific modification of nucleic acids by an oligonucleotide incorporating a S-vinyl thioguanosine analog, has great potential as a useful tool. The specific transfer of the vinyl derivative to the amino group of dC at the target site of the complementary ODN has been demonstrated. This is an innovative method for the efficient and selective modification of the target cytidine in DNA

Footnotes

**This work was supported by Grant-in-Aid for Scientific Research (A) from Japan Society for the Promotion of Science (JSPS). CREST from Japan Science and Technology Agency (JST).


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