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Nucleic Acids Symposium Series 2007 51(1):61; doi:10.1093/nass/nrm031
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© 2007 Oxford University Press

Making Oligonucleotide Conjugates and Breaking Oligonucleotides

S. Milton, M. Murtola, J. Sandbrink, E. Yeheskiely and R. Strömberg*

Department of Biosciences & Nutrition, Novum, Karolinska Institutet, S-14157 Huddinge, Sweden

*Corresponding author: Roger Strömberg E-mail: Roger.Stromberg{at}biosci.ki.se

Abstract

ABSTRACT Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2’-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups. Recent results on cleavage of RNA by artificial nucleases, is also presented.


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