© 2007 Oxford University Press
Making Oligonucleotide Conjugates and Breaking Oligonucleotides
Department of Biosciences & Nutrition, Novum, Karolinska Institutet, S-14157 Huddinge, Sweden
*Corresponding author: Roger Strömberg E-mail: Roger.Stromberg{at}biosci.ki.se
Abstract
ABSTRACT Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups. Recent results on cleavage of RNA by artificial nucleases, is also presented.