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Nucleic Acids Symposium Series 2007 51(1):69-70; doi:10.1093/nass/nrm035
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© 2007 Oxford University Press

Conformationally-2',4'-Locked Aza-ENA and Carbocyclic ribo-Thymidine

Jyoti Chattopadhyaya*

Department of Bioorganic Chemistry, Box 581, Biomedical Centre, Uppsala University, SE-75123 Uppsala, Sweden

* jyoti{at}boc.uu.se

Abstract

AONs containing aza-ENA (1), 5-membered (2) and 6-membered (3) carbocyclic analogs of LNA (carbocyclic-LNA-T) and ENA (carbocyclic-ENA-T) are both nuclease resistant and capable of eliciting RNase H response, very similar to that of the native.


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