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Nucleic Acids Symposium Series 2007 51(1):79-80; doi:10.1093/nass/nrm040
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© 2007 Oxford University Press

Spectroscopic studies on a novel intramolecular hydrogen bond within the (6–4) photoproduct

Junpei Yamamoto1,*, Yoshiyuki Tanaka2, Kenichi Hitomi1,3, Elizabeth D. Getzoff3 and Shigenori Iwai1

1Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan, 2Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi, Japan, 3Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

*Corresponding author. yamagen{at}chembio.chem.es.osaka-u.ac.jp

Abstract

The (6–4) photoproduct, which is one of major UVinduced lesions formed between adjacent pyrimidine bases in DNA, was characterized by using 15N NMR, fluorescence emission, and UV/VIS absorption at various pH values. From these experiments, we identified a novel intramolecular hydrogen bond between the hydroxyl group at the C5 position of the 5' component and the N3 of the 3’ pyrimidone ring within the (6–4) photoproduct.


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